Doug and Griff have been best friends since childhood and have always dreamed of making a remake of their all-time favorite film: the classic "Anaconda." When a midlife crisis pushes them to take on the challenge, they head deep into the Amazon to begin filming. But things take a turn for the worse when a real, giant anaconda appears, transforming their comically chaotic set into a deadly place. The film they're so desperate to make? It might just get them killed...