Frankie (Kristen Stewart) is chaos personified, and Molly (Alia Shawkat) is a culinary talent. Together, they form a duo who are completely unable to cope with adulthood, much less... paying the rent regularly. When Frankie accidentally picks up a mysterious suitcase with an experimental substance at a party, the friends' lives take a total plot twist. The girls drink fluorescent shots and suddenly gain the ability to telepathy. From now on, they not only communicate without words, but they can also hear their cats' thoughts!